Rookie Running Back Isaac Guerendo Steps into Spotlight Amid 49ers Injuries
Isaac Guerendo, a fourth-round pick in the 2024 NFL Draft, is suddenly in the spotlight after injuries to both Christian McCaffrey and Jordan Mason have left the San Francisco 49ers’ backfield thin. The rookie running back, known for his blistering speed and physical style of play, now has a golden opportunity to prove himself as a key contributor in the 49ers’ explosive offense. With his college career being more of a slow burn, Guerendo’s path to the NFL hasn’t been the most conventional. But now, with the stakes higher than ever, it’s time for him to show he can live up to the promise that got him drafted in the first place.
Guerendo’s journey to the pros is a story of resilience and versatility. He started his college career at Wisconsin but struggled to get significant playing time. A move to Louisville allowed him to shine, and his performance at the 2024 NFL Combine only boosted his stock. A 4.33-second 40-yard dash turned heads, showcasing his elite speed and burst. His ability to hit top speed quickly, combined with his vision and agility, make him a dual threat—both as a rusher and a pass-catching option out of the backfield. Scouts rave about his mix of size, speed, and playmaking instincts, not to mention his strong blocking skills, which are essential in the NFL.
Still, despite his natural talent, there are some lingering questions about whether Guerendo can turn his potential into consistent production at the next level. Having never been a full-time starter in college, some doubt whether he can handle the physical demands of an NFL backfield, particularly as a pass protector or in short-yardage situations. His preference for running to the outside and his need for more development in changing direction could limit his immediate impact. But with his high ceiling and room to grow, Guerendo is an intriguing prospect for the 49ers, who will be watching closely to see if he can step up and become a reliable option while their star backs recover.